[bioinfo] CS 591 BIO: Talk tomorrow by Mao-Feng Ger on analysis of glutamine receptor channels
sinhas at uiuc.edu
Thu Mar 1 13:52:06 CST 2007
Our speaker for tomorrow's seminar is Mao-Feng Ger, PhD student in
Biophysics in Eric Jakobsson's lab. Mao-Feng will be speaking on
recent results in bioinformatics analysis of glutamine receptor
channels. More details of the talk are given below.
TIME: 10:30 AM - 11:30 AM.
DATE: Friday, March 2.
PLACE: 3401 Siebel Center.
Glutamate Receptor Ion Channels and their relatives in Bacteria and
While ion channels play different vital roles in eukaryotic species,
many prokaryotic ion channels are found recently. Compared to their
eukaryotic homologues, most prokaryotic ion channels remain
functionally unknown. One of the prokaryotic ionotropic glutamate
receptor ion channel (iGluR) has been characterized. It can bind
glutamate, but transport potassium ions specifically. In this
research, we tried to find more prokaryotic iGluRs based on the
topology analysis, motif analysis and other methods. We found two
groups of prokaryotic genes which may be the ancestor of eukaryotic
iGluRs. They are with the domains which confer ligand-binding
capability and ions permeability and have the same topology as
eukaryotic iGluRs. One of these two groups contains the previously
characterized prokaryotic iGluR, but the other group has greater
homology to eukaryotic iGluRs.
In the future work, we will expand our iGluR search all over
Bacteria, Archaea, and Eukaryota. Then, with these sequences,
homology modeling, domain analysis and phylogenetic analysis will be
processed to realize their probable structures, functions and
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